N MEFTAH; MR RABIEI; GHR ROUSHANDEL; S BESHARAT; A JABARI; SH SEMNANI; R AZARHOUSH; N ABDOLLAHI
Volume 13, Issue 2 , July and August 2006, , Pages 74-79
Abstract
Background and Purpose: P53 gene is a tumor suppressive gene and its product, P53 protein, is a protective factor against tumor formation that inhibits the extension of genetically damaged cells. P53 aggregation in tumoral cell nucleus is related with p53 gene mutations, which can be detected by immunohistochemical ...
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Background and Purpose: P53 gene is a tumor suppressive gene and its product, P53 protein, is a protective factor against tumor formation that inhibits the extension of genetically damaged cells. P53 aggregation in tumoral cell nucleus is related with p53 gene mutations, which can be detected by immunohistochemical methods. This study was designed to investigate the protein aggregation in patients with gastric cancer in Gorgan, Iran.
Methods and materials: All paraffin-embedded blocks of gastric cancer cases during the years 2000 to 2004 in the pathology ward of the 5th Azar Hospital in Gorgan, Iran (111 cases altogether) were evaluated and stained, for detecting microtome cutting. The obtained data were entered into SPSS and chi-square was used for analysis.
Results: 111 cases with gastric cancer were investigated. The most frequent type of gastric tumor was adenocarcinoma (66.7%). In 59.5% of the affected cases, P53 protein was detected. No significant relationship was observed between P53 expression and factors such as age, gender, and histological type of the tumor.
Conclusions: In this study, P53 protein rate was high but it showed no significant relationship with other variables. We suggest further studies to discover the relationship between protein aggregation in tumor cells and other variables in affected cases.